Elevated crp concentrations may significantly influence the occurrence of cerebro and cardiovascular events. Subclinical atherosclerosis in patients with psoriasis article pdf available in journal of the saudi heart association 273 march 2015 with 46 reads how we measure reads. Longterm exposure to ambient particulate matter and prevalence of subclinical atherosclerosis in the multiethnic study of atherosclerosis. In summary, our study demonstrates that subclinical atherosclerosis determined by carotid imt, carotid plaque score, and coronary artery calcium score in the absence of clinical cardiovascular event are significantly associated with parameters of left ventricular dyssynchrony as a marker of subclinical regional myocardial dysfunction. Furthermore, the relationships between risk factors and markers of subclinical atherosclerosis in art and nonart groups were similar. Femoral and carotid subclinical atherosclerosis association. Subclinical atherosclerosis was defined as the presence of atherosclerotic plaques in the carotid, aortic, or iliofemoral territories or cacs.
Particulate matter and subclinical atherosclerosis. A total of 89 fh and 50 nfh patients underwent ct with coronary and thoracic aorta calcium scoring. We investigated the role of subclinical carotid atherosclerosis for the prediction of adverse cardiovascular cv outcomes in these patients, and tried to identify clinical and echocardiographic parameters associated with subclinical carotid atherosclerosis. Assessment of subclinical atherosclerosis using computed. Are we ready for routine subclinical atherosclerosis screening. Pdf the presence of subclinical atherosclerosis is a likely predictor of cardiovascular events. Data sources pubmed medline was systematically searched on 7 september 2011. Objectives we evaluated whether twodimensional highresolution transthoracic echocardiography hr2dtte can detect changes in arterial wall thickness and size associated with subclinical coronary artery disease cad. Subclinical atherosclerosis burden predicts cardiovascular events in. Dietary zinc intake is inversely related to subclinical. The process of atherosclerosis the build up of fatty plaques in all arteries occurs silently and often the first symptom is sudden death due to a heart attack.
We retrospectively enrolled 914 selfreferred asymptomatic subjects under the age of 45 552 men, 362 women who had undergone both coronary ct angiography ccta and coronary artery calcium scoring. Maria felicia faienza 1, angelo acquafredda 1, riccardina tesse 1, vincenza luce 1, annamaria ventura 1, nicola maggialetti 2, mariantonietta monteduro 2, paola giordano 1, luciano cavallo 1. Inflammation has been involved in the development of atherosclerosis, type 2 diabetes mellitus, insulin resistance, and obesity. Background myocardial infarction is an important risk factor for atrial fibrillation, but the role of subclinical atherosclerosis is unknown. Association between nonalcoholic fatty liver disease and. This is a temporary file and hence do not link it from a website, instead link the url of this page if you wish to link the pdf file. Interleukin 20 is a proinflammatory cytokine encoded by a polymorphic gene located in chromosome 1. Single measures of cvh during adolescence and young adulthood have been associated with the incidence of hypertension, metabolic syndrome, and hyperlipidemia and an increased burden of subclinical atherosclerosis. Imaging subclinical atherosclerosis holds the promise of individualized cardiovascular cv risk assessment.
From subclinical atherosclerosis to plaque progression and. Atherosclerotic disease starts at an early age and follows a subclinical course for decades, becoming apparent in the fifth or sixth decades of life. The project identified factors affecting implementation of evidencebased noninvasive screening tests to identify early stage cardiovascular disease cvd. Longitudinal association between serum urate and subclinical atherosclerosis.
Subclinical atherosclerosis, measured by carotid artery mean imt and plaque, was found to be related to about a 15% increased risk of hearing impairment during a 5year followup period and with lower hearing sensitivity at followup in this large, primarily middleaged cohort. Cardiovascular quality and outcomes, the journal of the american heart association, one can read a very interest ing article entitled quantifying the utilit y of taking pills for cardiovascular. Wang h, jacobs dr jr, gaffo al, gross md, goff dc jr, carr jj. The pesa progression of early subclinical atherosclerosis study rationale and design have been described elsewhere19. Screening asymptomatic subjects for subclinical atherosclerosis. This longitudinal study evaluates whether atherosclerosis affects the risk of atrial fibrillation in persons without overt coronary disease. If you do not see its contents the file may be temporarily unavailable at the journal website or you do not have a pdf plugin installed and enabled in your browser. Subclinical atherosclerosis present in many adults without. Several studies showed also the increasing of the prevalence of subclinical atherosclerosis, but there are little data from subsaharan africa. Objectives the purpose of this study was to analyze the temporal and topologically resolved protein changes taking place in human aortas with early atherosclerosis to find new potential diagnostic andor therapeutic. While the disease is still in a subclinical stage, however, the presence of atherosclerosis can be identified by several methods, including coronary angiography, intravascular ultrasonography, bmode ultrasonography, computed. Arteries are blood vessels that carry oxygenrich blood to your heart and other parts of your body. Several studies have suggested that inflammation may be important for accelerated progression of atherosclerosis, but few data are available on subjects with early stages of. These techniques can ascertain parameters such as luminal diameter or stenosis, vessel wall thickness, plaque volume, and the specific distribution and.
Results from offline manual and automated measurements of the same cimt studies have been compared by several investigators and have. When subclinical atherosclerosis was defined as 80th percentile value of imt or. Association of subclinical atherosclerosis using carotid. Atherosclerosis imaging allows direct visualisation of the cumulative effect of all risk. Gestational diabetes mellitus gdm is associated with an elevated risk of adverse health outcomes such as type 2 diabetes and cardiovascular diseases. Atherosclerosis is a chronic, progressive, inflammatory disease with a long asymptomatic phase. Serum uric acid predicts progression of subclinical coronary atherosclerosis in individuals without renal disease.
This study evaluated the ability of the triglyceride glucose tyg index to predict subclinical coronary artery disease cad in asymptomatic subjects without traditional cv risk factors cvrfs. The study also evaluated predictors of cardiac events. Assessment of subclinical atherosclerosis in systemic. Early detection of subclinical atherosclerotic burden by multiterritorial vascular ultrasound could improve cve prediction in this population.
Nondiabetic chronic kidney disease ckd patients are a heterogeneous group with a variety of prognosis. Plaque is made up of fat, cholesterol, calcium, and. Risk factors for subclinical atherosclerosis in diabetic. This retrospective, crosssectional, and observational study evaluated the association of tyg index. Likewise, application of this approach to the subclinical measures of atherosclerosis reveals novel gene discoveries which open new. Racialethnic differences in subclinical atherosclerosis. American heart association ideal cardiovascular health. From subclinical atherosclerosis to plaque progression and acute coronary events. Assessment of noninvasive risk markers of subclinical. Background the mechanisms underlying early atherosclerotic plaque formation are not completely understood. Unhealthy snacks consumption is associated with obesity and other cvd risk factors in children and adolescents.
Subclinical coronary atherosclerosis in young adults. Association between serum level of urate and subclinical. Noninvasive markers of subclinical atherosclerosis for. Kce report 244cs noninvasive markers of subclinical atherosclerosis 1 foreword in the march 2015 issue of circulation.
Individuals with diabetes have remarkably high rates of cardiovascular morbidity and mortality. Atherosclerotic cardiovascular disease leading to coro nary heart disease and stroke continue to be the leading causes of morbidity and mortality in much of the. The use of coronary artery calcium scores and carotid intima media thickness testing improves accuracy of risk stratification over risk factor scoring systems alone. Imaging markers of subclinical atherosclerosis keesik kim, md division of cardiology, daegu catholic university, medical center, daegu, korea abstract atherosclerosis is a generalized disorder that progresses very slowly. Prevalence, vascular distribution, and multiterritorial extent of. Detection of subclinical coronary atherosclerosis using. Biomolecules free fulltext common variants in il20. Association of nuts and unhealthy snacks with subclinical. Cardiovascular cv disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. Techniques for measuring subclinical atherosclerosis. Risk factors for subclinical atherosclerosis in diabetic and obese children. The aim of this study was to investigate in a populationbased cohort age range, 5064 years stratified by sex the association between the serum urate su concentration and subclinical atherosclerosis, as reflected in the coronary artery calcification cac score, common carotid intimamedia thickness cimt, and carotid plaque score. The study shows that plasma levels of the complement system protein c5 could be used to identify individuals with subclinical atherosclerosis in a noninvasive way and at minimal cost. Atherosclerosis is the most common cardiovascular disease and accounts for the greatest number of deaths.
Background arterial wall thickening, compensatory arterial enlargement and a preserved arterial lumen characterize subclinical atherosclerosis. Whether there is a direct correlation between gdm and elevated cimt is still controversial. Examining the large arteries in the neck the carotids with ultrasound for early fatty plaques continue reading searching for. A variety of invasive and noninvasive techniques are available to measure atherosclerosis and subclinical atherosclerosis table 2. Dna damage and subsequent repair pathways have been involved in the initiation and progression of atherosclerosis. Subclinical atherosclerosis burden predicts cardiovascular.
Cardiovascular magnetic resonance imaging cmri allows noninvasive detection of coronary artery stenoses 5 and imaging of atherothrombosis in the aorta 6,7 and carotid 8 and coronary arteries. The process of atherosclerosis begins early in childhood and usually remains asymptomatic until later in life. Subclinical carotid atherosclerosis and inflammation. Mre11a polymorphisms are associated with subclinical. Detection of subclinical atherosclerosis by noninvasive measures. Association between alcohol consumption and subclinical. Subclinical atherosclerosis and impaired cardiac autonomic control in pediatric patients with vitamin b12 deficiency. Subclinical atherosclerosis, cardiovascular health, and disease risk.
Carotid intimamedia thickness cimt is increasingly used as a noninvasive marker for subclinical atherosclerosis. Subclinical atherosclerosis and increased risk of hearing. Stepwise logistic regression revealed that current drinker or and 95% ci. Association of gestational diabetes mellitus gdm with. Pdf the progression and early detection of subclinical. Noninvasive assessment of subclinical atherosclerosis in children. The association of fli and nfs with subclinical atherosclerosis on ccta is shown. The aim of our study was to assess the prevalence of cardiovascular risk factors, subclinical. Disease progression can lead eventually to the occurrence of acute cardiovascular events such as myocardial infarction, unstable angina pectoris and sudden cardiac death.
Factors associated with elevated cimt and subclinical atherosclerosis. Scientists identify new biomarker to detect subclinical. However, there is a debate about the advisability of clinical screens for subclinical atherosclerosis and which. Further research is warranted in larger and older cohorts to be able to evaluate possible associations between art and clinical cvd. Characterization of intravascular cellular activation in. Progression of early subclinical atherosclerosis full.
The advent of genomewide association studies has allowed for considerable progress in identi. Subclinical atherosclerosis, inflammation and events. While the disease is still in a subclinical stage, however, the presence of atherosclerosis can be identified by several methods, including coronary angiography. The purpose of this study was to analyse the prognostic value of subclinical atherosclerosis in determining the incidence of first cardiovascular events cves in individuals. Subclinical atherosclerosis vascular evaluation save.
Atherosclerotic cardiovascular cv events commonly occur in individuals with a low cv risk burden. Risk factors of subclinical atherosclerosis and plaque. Pdf subclinical atherosclerosis in patients with psoriasis. Meiotic recombination 11 homolog a mre11a gene polymorphisms have been associated with the presence of myocardial infarction. The pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader if you would like more information about how to print, save, and work with pdfs, highwire press provides a helpful frequently asked questions about pdfs alternatively, you can download the pdf file directly to your computer, from where it. Cardiovascular health trajectories from childhood through. We analyzed five mre11a gene polymorphisms in 386 individuals with subclinical atherosclerosis and 1093 healthy controls. Subclinical atherosclerosis is associated with incident. Subclinical cardiovascular disease in older adults. Diabetic retinopathy is associated with the presence and. Subclinical atherosclerosis and impaired cardiac autonomic.
Tests that measure subclinical atherosclerosis can be useful for people who want to know if they are at an increased risk of cardiovascular disease. Moreover, plasma biomarkers of subclinical atherosclerosis are lacking. However, the incremental cardiovascular risk in diabetes is heterogeneous and has often been related to renal involvement. Context imaging for subclinical atherosclerosis on top of conventional risk factor assessment may improve risk prediction for the occurrence of cardiovascular disease events in asymptomatic individuals.
Early subclinical atherosclerosis was present in approximately onehalf of middleaged adults who were free from cv risk factors, according to results published in the journal of the american. The aim of the study was to assess the association of the frequency and the burden of subclinical carotid atherosclerotic disease in patients with type 1 diabetes according to the presence and severity of diabetic retinopathy dr. Subclinical coronary and aortic atherosclerosis detected. The large arsenal of noninvasive imaging techniques available today is playing an increasingly important role in the diagnosis and monitoring of subclinical atherosclerosis. Further research to explore how these ethnic differences in subclinical atherosclerosis relate to clinical outcomes in persons with diabetes is. Author links open overlay panel amir ahmadi md a b edgar argulian md a jonathon leipsic md b david e. The prevalence of subclinical atherosclerosis was higher in the sle patients than in the healthy controls, as demonstrated by a statistically significant increase in the cp number and cimt value and a decrease in fmd. Subclinical atherosclerosis can be assessed using different measures. Subclinical hypothyroidism is an independent risk factor. Predicting subclinical atherosclerosis in lowrisk individuals.
The multiethnic study of atherosclerosis mesa is a study of the characteristics of subclinical cardiovascular disease disease detected noninvasively before it has produced clinical signs and symptoms and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease. It is the main contributor to the clinical burden of cvd and subclinical forms of atherosclerosis constitute a risk for and are predictive of future cardiovascular events cve 6. Cardiovascular risk and subclinical atherosclerosis in. Rheumatoid arthritis ra is associated with increasing of cardiovascular cv morbidity and mortality due to accelerated atherosclerosis. Improvements in risk stratification for the occurrence of. Characterization of intravascular cellular activation in relationship to subclinical atherosclerosis in postmenopausal women plos one, nov 2019 muthuvel jayachandran, vesna d.
Subclinical atherosclerosis is a fancy term doctors use to describe the early stages of atherosclerosis that can occur throughout the body. Cimt is a noninvasive technique to detect subclinical atherosclerosis and is associated with multiple. Subclinical measures of atherosclerosis repub, erasmus. Carotid intimamedia thickness is a measurement of the combined thickness of the intimal and medial layers of the carotid artery by bmode ultrasound. Ive discussed in a previous post the importance of detecting subclinical atherosclerosis. Carotid intimamedia thickness cimt as a marker of subclinical atherosclerosis could identify early vascular alterations. Subclinical atherosclerosis is an early indicator of atherosclerotic burden and its timely recognition can slow or prevent progression to cvd. We aimed to estimate the impact of alcohol intake on the presence of subclinical atherosclerosis in femoral arteries in smoking and non. The purpose of this study was to assess the characteristics and predictors of subclinical coronary atherosclerosis in young adults.
Results subclinical atherosclerosis was found in 72% of participants. The purpose of this project was to identify nps perceived barriers to. Table 1 markers of subclinical atherosclerosis evaluated in this. These findings in a population based asymptomatic cohort provide important insights into the mechanisms and pathways of atherosclerosisrelated incipient lv. The aim of the study was to evaluate the association of two il20 polymorphisms rs1400986 and rs1518108 with subclinical atherosclerosis sa, cardiovascular risk.
227 1097 383 79 453 1092 306 1313 443 217 634 1546 1405 631 592 367 1414 292 1030 1214 1159 782 904 1085 1150 710 29 536 522 546 1189 1356 724 1054 677 571